Issue 4, 2012
From the journal:

MedChemComm

Squaric acid: a valuable scaffold for developing antimalarials?†

S. Praveen Kumar,a   Paulo M. C. Glória,a   Lídia M. Gonçalves,a   Jiri Gut,b   Philip J. Rosenthal,b   Rui Moreiraa  and  Maria M. M. Santos*a  

* Corresponding authors

a Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL), Faculty of Pharmacy, University of Lisbon, Av. Prof. Gama Pinto, 1649-003 Lisbon, Portugal
E-mail: mariasantos@ff.ul.pt
Fax: 351 21 794 6470
Tel: 351 21 794 6400

b Department of Medicine, San Francisco General Hospital, University of California, San Francisco, CA 94143, USA

Abstract

We describe here the synthesis of a library of thirty-eight squaric derivatives and the evaluation of activity against papain-, falcipain-2- and a chloroquine-resistant strain of P. falciparum. The most active compounds combine significant antiplasmodial activity with minimal cytotoxicity.

Graphical abstract: Squaric acid: a valuable scaffold for developing antimalarials?

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C2MD20011B
Article type
Concise Article
Submitted
19 Jan 2012
Accepted
05 Feb 2012
First published
08 Feb 2012

Med. Chem. Commun., 2012,3, 489-493

Permissions

Request permissions

Squaric acid: a valuable scaffold for developing antimalarials?

S. P. Kumar, P. M. C. Glória, L. M. Gonçalves, J. Gut, P. J. Rosenthal, R. Moreira and M. M. M. Santos, Med. Chem. Commun., 2012, 3, 489 DOI: 10.1039/C2MD20011B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements