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Issue 8, 2012
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Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection

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Abstract

Sangamides are amide derivatives of sanglifehrin A, a cyclophilin-binding polyketide natural product which is structurally distinct from cyclosporine A. Cyclosporine A is the starting point for the synthesis of cyclophilin inhibitors such as alisporivir, currently in development for the treatment of HCV infection. We report here initial results of the optimisation program which led to identification of the sangamides, compounds that exhibit significantly improved potential for the treatment of chronic HCV infection.

Graphical abstract: Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection

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Publication details

The article was received on 06 Sep 2011, accepted on 02 Oct 2011 and first published on 21 Oct 2011


Article type: Concise Article
DOI: 10.1039/C1MD00227A
Citation: Med. Chem. Commun., 2012,3, 944-949
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    Sangamides, a new class of cyclophilin-inhibiting host-targeted antivirals for treatment of HCV infection

    S. J. Moss, M. Bobardt, P. Leyssen, N. Coates, U. Chatterji, X. Dejian, T. Foster, J. Liu, M. Nur-e-Alam, D. Suthar, C. Yongsheng, T. Warneck, M. Zhang, J. Neyts, P. Gallay, B. Wilkinson and M. A. Gregory, Med. Chem. Commun., 2012, 3, 944
    DOI: 10.1039/C1MD00227A

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