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Issue 1, 2012
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Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

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Abstract

A small library of ferrocene-based 1,2,3-triazole-containing hydroxamic acids has been synthesised employing click chemistry: 7-(4-ferrocenyl-1H-1,2,3-triazol-1-yl)-N-hydroxyheptanamide, 4b, containing the 1,2,3-triazole moiety adjacent to the ferrocene group, displayed excellent HDAC inhibition and activity in cells, inhibiting the deacetylation of tubulin as well as inducing cell cycle arrest.

Graphical abstract: Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

  • This article is part of the themed collection: Epigenetics
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The article was received on 06 Aug 2011, accepted on 28 Sep 2011 and first published on 20 Oct 2011


Article type: Concise Article
DOI: 10.1039/C1MD00203A
Citation: Med. Chem. Commun., 2012,3, 61-64
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    Click JAHAs: conformationally restricted ferrocene-based histone deacetylase inhibitors

    J. Spencer, J. Amin, R. Boddiboyena, G. Packham, B. E. Cavell, S. S. Syed Alwi, R. M. Paranal, T. D. Heightman, M. Wang, B. Marsden, P. Coxhead, M. Guille, G. J. Tizzard, S. J. Coles and J. E. Bradner., Med. Chem. Commun., 2012, 3, 61
    DOI: 10.1039/C1MD00203A

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