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Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Avenida Antônio Carlos 6627, Belo Horizonte, Brazil
; Fax: +55-31-3409-6935
; Tel: +55-31-3409-6395
Med. Chem. Commun., 2012,3, 1219-1227
10 May 2012,
17 Jun 2012
First published online
19 Jun 2012
Phosphofructokinase is an enzyme of central importance to carbohydrate metabolism and is subject to regulation by a considerable number of allosteric ligands. This review is a survey of the recent literature concerning structural and functional properties of the enzyme phosphofructokinase as well as its importance as target for the development of selective therapeutics for trypanosomiasis.
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