Jump to main content
Jump to site search

Issue 10, 2012
Previous Article Next Article

Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease

Author affiliations

Abstract

Benzyloxy-2-chloroquinoline was reacted with fluorine-18 labelled potassium cryptand fluoride, followed by catalytic hydrogenation to prepare [18F]2-fluoroquinolin-8-ol in high radiochemical yields (30%; uncorrected and relative to [18F]-fluoride), specific activities (>1 Ci μmol−1) and radiochemical purities (>99%) within 70 min; PET-CT imaging with this new radiotracer in double transgenic mice shows excellent promise for imaging Alzheimer's disease.

Graphical abstract: Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 22 Mar 2012, accepted on 22 Mar 2012 and first published on 23 Mar 2012


Article type: Concise Article
DOI: 10.1039/C2MD20075A
Citation: Med. Chem. Commun., 2012,3, 1228-1230
  •   Request permissions

    Synthesis and PET imaging studies of [18F]2-fluoroquinolin-8-ol ([18F]CABS13) in transgenic mouse models of Alzheimer's disease

    N. Vasdev, P. Cao, E. M. van Oosten, A. A. Wilson, S. Houle, G. Hao, X. Sun, N. Slavine, M. Alhasan, P. P. Antich, F. J. Bonte and P. Kulkarni, Med. Chem. Commun., 2012, 3, 1228
    DOI: 10.1039/C2MD20075A

Search articles by author