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Issue 5, 2012
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Oxadiazole isomers: all bioisosteres are not created equal

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Abstract

Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.

Graphical abstract: Oxadiazole isomers: all bioisosteres are not created equal

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Publication details

The article was received on 22 Feb 2012, accepted on 15 Mar 2012 and first published on 16 Mar 2012


Article type: Concise Article
DOI: 10.1039/C2MD20054F
Citation: Med. Chem. Commun., 2012,3, 600-604
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    Oxadiazole isomers: all bioisosteres are not created equal

    K. Goldberg, S. Groombridge, J. Hudson, A. G. Leach, P. A. MacFaul, A. Pickup, R. Poultney, J. S. Scott, P. H. Svensson and J. Sweeney, Med. Chem. Commun., 2012, 3, 600
    DOI: 10.1039/C2MD20054F

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