Issue 9, 2012
From the journal:

MedChemComm

Synthesis of a novel thiophene derivative that induces cancer cell apoptosis through modulation of AKT and MAPK pathways†

Yi Luo,a   Xiaoling Li,a   Tianfeng Chen,*a   Yi Wanga  and  Wenjie Zheng*a  

* Corresponding authors

a Department of Chemistry, Jinan University, Guangzhou 510632, P. R. China
E-mail: felixchentf@gmail.com, tzhwj@jnu.edu.cn
Tel: +86 020-85225962

Abstract

A novel thiophene-based compound N-(4′-hydroxyphenyl)-2,5-di(2′′-thienyl)pyrrole (SNS-OH) has been synthesized and evaluated for its in vitro anticancer activities. The results showed SNS-OH effectively induced apoptosis in neuroblastoma cells through regulating the AKT and MAPK pathways.

Graphical abstract: Synthesis of a novel thiophene derivative that induces cancer cell apoptosis through modulation of AKT and MAPK pathways

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Article information

DOI
https://doi.org/10.1039/C2MD20041D
Article type
Concise Article
Submitted
13 Feb 2012
Accepted
26 Jun 2012
First published
28 Jun 2012

Med. Chem. Commun., 2012,3, 1143-1146

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Synthesis of a novel thiophene derivative that induces cancer cell apoptosis through modulation of AKT and MAPK pathways

Y. Luo, X. Li, T. Chen, Y. Wang and W. Zheng, Med. Chem. Commun., 2012, 3, 1143 DOI: 10.1039/C2MD20041D

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