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Issue 8, 2012
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Natural product inhibitors of glucose-6-phosphate translocase

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Inhibitors of glucose-6-phosphate translocase (G6P T1) control aberrant glucose levels and show promise as anticancer and anti-diabetic agents. This mini-review provides a concise overview of natural product and natural product analogs that inhibit G6P T1. The discovery and development of these inhibitors, as well as their efficacy in cell-based assays and in vivo, are discussed. Finally, we acknowledge the need for improved G6P T1 inhibitors and the potential to harness the programmable chemistry of microorganisms to meet this need.

Graphical abstract: Natural product inhibitors of glucose-6-phosphate translocase

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Publication details

The article was received on 18 Jan 2012, accepted on 14 Mar 2012 and first published on 23 Apr 2012

Article type: Review Article
DOI: 10.1039/C2MD20008B
Citation: Med. Chem. Commun., 2012,3, 926-931
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    Natural product inhibitors of glucose-6-phosphate translocase

    L. K. Charkoudian, B. P. Farrell and C. Khosla, Med. Chem. Commun., 2012, 3, 926
    DOI: 10.1039/C2MD20008B

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