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Issue 5, 2012
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The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

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Abstract

A new pentacyclic compound, DDD-016 (10d) was designed and synthesized as a potential antipsychotic and screened for binding affinity in a broad panel of over 80 CNS and other receptors, monoamine transporters, and ion channels. The resulting receptor binding profile of DDD-016 is consistent with that of an improved atypical antipsychotic candidate.

Graphical abstract: The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

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Publication details

The article was received on 21 Dec 2011, accepted on 06 Mar 2012, published on 07 Mar 2012 and first published online on 07 Mar 2012


Article type: Concise Article
DOI: 10.1039/C2MD00311B
Citation: Med. Chem. Commun., 2012,3, 580-583
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    The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic

    A. Bandyopadhyaya, D. R. Rajagopalan, N. P. Rath, A. Herrold, R. Rajagopalan, T. C. Napier, C. E. Tedford and P. Rajagopalan, Med. Chem. Commun., 2012, 3, 580
    DOI: 10.1039/C2MD00311B

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