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Issue 6, 2012
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Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

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Abstract

Cyclometalated rhodium complexes were synthesized and evaluated as JAK2 metal-based inhibitors. Complexes 1 and 2 inhibited JAK2 enzyme phosphorylation activity, reduced JAK2 autophosphorylation in cellulo and exhibited cytotoxicity towards HEL cancer cells. To our knowledge, these are the first two examples of metal-based inhibitors of JAK2.

Graphical abstract: Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

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Publication details

The article was received on 14 Dec 2011, accepted on 07 Apr 2012 and first published on 16 Apr 2012


Article type: Concise Article
DOI: 10.1039/C2MD00306F
Citation: Med. Chem. Commun., 2012,3, 696-698
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    Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

    C. Leung, H. Yang, V. P. Ma, D. S. Chan, H. Zhong, Y. Li, W. Fong and D. Ma, Med. Chem. Commun., 2012, 3, 696
    DOI: 10.1039/C2MD00306F

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