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Issue 3, 2012
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New fluorinated 1,4-bis-(arylaminomethyl)- and 1,4-bis-(arylaminomethylene)benzenes as fluorescent probes for amyloid plaques in Alzheimer's disease and transmissible spongiform encephalopathies

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Abstract

The research into selective ligands of misfolded protein plaques in Alzheimer's disease and in transmissible spongiform encephalopathies led to compound 3, based on the Congo Red framework and bearing two trifluoromethoxy groups. Histochemical experiments on human brain tissues showed intense fluorescent staining of fibrillary deposits in both pathologies.

Graphical abstract: New fluorinated 1,4-bis-(arylaminomethyl)- and 1,4-bis-(arylaminomethylene)benzenes as fluorescent probes for amyloid plaques in Alzheimer's disease and transmissible spongiform encephalopathies

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Publication details

The article was received on 07 Oct 2011, accepted on 25 Nov 2011 and first published on 30 Nov 2011


Article type: Concise Article
DOI: 10.1039/C2MD00254J
Citation: Med. Chem. Commun., 2012,3, 357-361
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    New fluorinated 1,4-bis-(arylaminomethyl)- and 1,4-bis-(arylaminomethylene)benzenes as fluorescent probes for amyloid plaques in Alzheimer's disease and transmissible spongiform encephalopathies

    C. Mustazza, M. Sbriccoli, A. Borioni, R. Ferretti and M. R. Del Giudice, Med. Chem. Commun., 2012, 3, 357
    DOI: 10.1039/C2MD00254J

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