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Issue 4, 2012
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Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

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Abstract

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however threatening to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6′-N-acetyltransferase (AAC(6′)).

Graphical abstract: Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

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Publication details

The article was received on 06 Oct 2011, accepted on 20 Nov 2011 and first published on 22 Nov 2011


Article type: Review Article
DOI: 10.1039/C2MD00253A
Citation: Med. Chem. Commun., 2012,3, 397-407
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    Understanding and overcoming aminoglycoside resistance caused by N-6′-acetyltransferase

    K. Vong and K. Auclair, Med. Chem. Commun., 2012, 3, 397
    DOI: 10.1039/C2MD00253A

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