Issue 2, 2012

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

Abstract

The design and synthesis of a potent series of c-jun N-terminal kinase (JNK2) inhibitors is described. The development and optimization of the 2,4-diaminopyrimidines series was carried out from an earlier in-house kinase inhibitor program. Through the optimization of the scaffold 2, several cell potent compounds with good in vivo profiles were discovered.

Graphical abstract: Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

Supplementary files

Article information

Article type
Concise Article
Submitted
26 Aug 2011
Accepted
03 Nov 2011
First published
01 Dec 2011

Med. Chem. Commun., 2012,3, 238-243

Synthesis and SAR of 2,4-diaminopyrimidines as potent c-jun N-terminal kinase inhibitors

X. Song, Y. He, M. Koenig, Y. Shin, R. Noel, W. Chen, Y. Y. Ling, D. Feurstein, L. Lin, C. H. Ruiz, M. D. Cameron, D. R. Duckett and T. M. Kamenecka, Med. Chem. Commun., 2012, 3, 238 DOI: 10.1039/C1MD00219H

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