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Issue 8, 2012
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Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells

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Abstract

Plant cells are characterized by the presence of chloroplasts, membrane lipids of which contain up to ∼80% mono- and digalactosyldiacylglycerol (MGDG and DGDG). The synthesis of MGDG in the chloroplast envelope is essential for the biogenesis and function of photosynthetic membranes, is coordinated with lipid metabolism in other cell compartments and is regulated in response to environmental factors. Phenotypic analyses of Arabidopsis using the recently developed specific inhibitor called galvestine-1 complete previous analyses performed using various approaches, from enzymology, cell biology to genetics. This review details how this probe could be beneficial to study the lipid homeostasis system at the whole cell level and highlights connections between MGDG synthesis and Arabidopsis flower development.

Graphical abstract: Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells

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Publication details

The article was received on 01 Mar 2012, accepted on 20 Apr 2012 and first published on 20 Apr 2012


Article type: Review Article
DOI: 10.1039/C2MB25067E
Citation: Mol. BioSyst., 2012,8, 2023-2035
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    Galvestine-1, a novel chemical probe for the study of the glycerolipid homeostasis system in plant cells

    L. Boudière, C. Y. Botté, N. Saidani, M. Lajoie, J. Marion, L. Bréhélin, Y. Yamaryo-Botté, B. Satiat-Jeunemaître, C. Breton, A. Girard-Egrot, O. Bastien, J. Jouhet, D. Falconet, M. A. Block and E. Maréchal, Mol. BioSyst., 2012, 8, 2023
    DOI: 10.1039/C2MB25067E

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