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Issue 6, 2012
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Metabolomic analysis of the plasma of patients with high-altitude pulmonary edema (HAPE) using 1H NMR

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Abstract

Upon rapid ascent to a high altitude, non-acclimatized individuals, although healthy, are highly prone to contracting high-altitude pulmonary edema (HAPE). Early diagnosis is difficult and there is no reliable biomarker available. We used proton (1H) NMR metabolomics to profile the altered metabolic patterns of blood plasma from HAPE patients. The plasmas of ten patients with HAPE and ten individuals without HAPE were collected and compared using 1H NMR spectroscopy. Data were evaluated with several multivariate statistical analyses, including the principal components, the orthogonal partial least-squares discriminant, and the orthogonal signal correction partial least-squares discriminant. Multivariate statistical analyses revealed a significant disparity between subjects with HAPE and those in the control group. Compared to the plasma of the controls, the HAPE patients had significant increases in valine, lysine, leucine, isoleucine, glycerol phosphoryl choline, glycine, glutamine, glutamic acid, creatinine, citrate, and methyl histidine. These were accompanied by decreases in α- and β-glucose, trimethylamine, and the metabolic products of lipids. The data demonstrate that metabolomics may be effective for the diagnosis of HAPE in the future, and can be used for further understanding HAPE pathogenesis.

Graphical abstract: Metabolomic analysis of the plasma of patients with high-altitude pulmonary edema (HAPE) using 1H NMR

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Publication details

The article was received on 09 Feb 2012, accepted on 12 Mar 2012 and first published on 15 Mar 2012


Article type: Paper
DOI: 10.1039/C2MB25044F
Citation: Mol. BioSyst., 2012,8, 1783-1788
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    Metabolomic analysis of the plasma of patients with high-altitude pulmonary edema (HAPE) using 1H NMR

    Y. Luo, J. Zhu and Y. Gao, Mol. BioSyst., 2012, 8, 1783
    DOI: 10.1039/C2MB25044F

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