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Issue 7, 2012
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More than just tails: intrinsic disorder in histone proteins

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Many biologically active proteins are disordered as a whole, or contain long disordered regions. These intrinsically disordered proteins/regions are very common in nature, abundantly found in all organisms, where they carry out important biological functions. The functions of these proteins complement the functional repertoire of “normal” ordered proteins, and many protein functional classes are heavily dependent on intrinsic disorder. Among these disorder-centric functions are interactions with nucleic acids and protein complex assembly. In this study, we present the results of comprehensive bioinformatics analyses of the abundance and roles of intrinsic disorder in 2007 histones from 746 species. We show that all the members of the histone family are intrinsically disordered proteins. Furthermore, intrinsic disorder is not only abundant in histones, but is absolutely necessary for various histone functions, starting from heterodimerization to formation of higher order oligomers, to interactions with DNA and other proteins, and to posttranslational modifications.

Graphical abstract: More than just tails: intrinsic disorder in histone proteins

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Publication details

The article was received on 17 Mar 2012, accepted on 07 Apr 2012 and first published on 12 Apr 2012

Article type: Paper
DOI: 10.1039/C2MB25102G
Citation: Mol. BioSyst., 2012,8, 1886-1901
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    More than just tails: intrinsic disorder in histone proteins

    Z. Peng, M. J. Mizianty, B. Xue, L. Kurgan and V. N. Uversky, Mol. BioSyst., 2012, 8, 1886
    DOI: 10.1039/C2MB25102G

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