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Issue 5, 2012
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Increasing the detection speed of an all-electronic real-time biosensor

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Abstract

Biosensor response time, which depends sensitively on the transport of biomolecules to the sensor surface, is a critical concern for future biosensor applications. We have fabricated carbon nanotube field-effect transistor biosensors and quantified protein binding rates onto these nanoelectronic sensors. Using this experimental platform we test the effectiveness of a protein repellent coating designed to enhance protein flux to the all-electronic real-time biosensor. We observe a 2.5-fold increase in the initial protein flux to the sensor when upstream binding sites are blocked. Mass transport modelling is used to calculate the maximal flux enhancement that is possible with this strategy. Our results demonstrate a new methodology for characterizing nanoelectronic biosensor performance, and demonstrate a mass transport optimization strategy that is applicable to a wide range of microfluidic based biosensors.

Graphical abstract: Increasing the detection speed of an all-electronic real-time biosensor

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Publication details

The article was received on 20 Oct 2011, accepted on 03 Jan 2012 and first published on 18 Jan 2012


Article type: Paper
DOI: 10.1039/C2LC21020G
Citation: Lab Chip, 2012,12, 954-959
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    Increasing the detection speed of an all-electronic real-time biosensor

    M. R. Leyden, R. J. Messinger, C. Schuman, T. Sharf, V. T. Remcho, T. M. Squires and E. D. Minot, Lab Chip, 2012, 12, 954
    DOI: 10.1039/C2LC21020G

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