Disposable roll-to-roll hot embossed electrophoresis chip for detection of antibiotic resistance gene mecA in bacteria

Ralph Liedert; Lotta K. Amundsen; Ari Hokkanen; Minna Mäki; Anne Aittakorpi; Mikko Pakanen; James R. Scherer; Richard A. Mathies; Marika Kurkinen; Sanna Uusitalo; Leena Hakalahti; Tarja K. Nevanen; Harri Siitari; Hans Söderlund

doi:10.1039/C1LC20782B

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Lab on a Chip

Issue 2, 2012

Miniaturisation for chemistry, physics, biology, materials science and bioengineering

Impact Factor 5.67 24 Issues per Year Indexed in MEDLINE

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Disposable roll-to-roll hot embossed electrophoresis chip for detection of antibiotic resistance gene mecA in bacteria

Ralph Liedert,*^a Lotta K. Amundsen,*^b Ari Hokkanen,^b Minna Mäki,^c Anne Aittakorpi,^c Mikko Pakanen,^b James R. Scherer,^d Richard A. Mathies,^d Marika Kurkinen,^a Sanna Uusitalo,^a Leena Hakalahti,^a Tarja K. Nevanen,^b Harri Siitari^e and Hans Söderlund^b

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VTT Technical Research Centre of Finland, Kaitoväylä 1, P.O. Box 1100, Oulu, Finland
E-mail: ralph.liedert@vtt.fi ;
Tel: +358 20 722 2337

VTT Technical Research Centre of Finland, Tietotie 2, P.O. Box 1000, Finland
E-mail: lotta.amundsen@vtt.fi ;
Tel: +358 20 722 4614

Mobidiag Ltd., Biomedicum 2U, Tukholmankatu 8, P.O. Box 63, Helsinki, Finland

University of California, College of Chemistry, 307 Lewis Hall, Berkeley, USA

VTT Technical Research Centre of Finland, Itäinen Pitkäkatu 4, P.O. Box 106, Turku, Finland

Lab Chip, 2012,12, 333-339

DOI: 10.1039/C1LC20782B
Received 19 Aug 2011, Accepted 08 Nov 2011
First published online 29 Nov 2011

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We present a high-throughput roll-to-roll (R2R) manufacturing process for foil-based polymethyl methacrylate (PMMA) chips of excellent optical quality. These disposable, R2R hot embossed microfluidic chips are used for the identification of the antibiotic resistance gene mecA in Staphylococcus epidermidis. R2R hot embossing is an emerging manufacturing technology for polymer microfluidic devices. It is based on continuous feeding of a thermoplastic foil through a pressurized area between a heated embossing cylinder and a blank counter cylinder. Although mass fabrication of foil-based microfluidic chips and their use for biological applications were foreseen already some years ago, no such studies have been published previously.

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