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Issue 18, 2012
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Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics

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Abstract

Effective pathogen detection is an essential prerequisite for the prevention and treatment of infectious diseases. Despite recent advances in biosensors, infectious diseases remain a major cause of illnesses and mortality throughout the world. For instance in developing countries, infectious diseases account for over half of the mortality rate. Pathogen detection platforms provide a fundamental tool in different fields including clinical diagnostics, pathology, drug discovery, clinical research, disease outbreaks, and food safety. Microfluidic lab-on-a-chip (LOC) devices offer many advantages for pathogen detection such as miniaturization, small sample volume, portability, rapid detection time and point-of-care diagnosis. This review paper outlines recent microfluidic based devices and LOC design strategies for pathogen detection with the main focus on the integration of different techniques that led to the development of sample-to-result devices. Several examples of recently developed devices are presented along with respective advantages and limitations of each design. Progresses made in biomarkers, sample preparation, amplification and fluid handling techniques using microfluidic platforms are also covered and strategies for multiplexing and high-throughput analysis, as well as point-of-care diagnosis, are discussed.

Graphical abstract: Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics

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Publication details

The article was received on 31 May 2012, accepted on 26 Jun 2012, published on 26 Jun 2012 and first published online on 26 Jun 2012


Article type: Critical Review
DOI: 10.1039/C2LC40630F
Citation: Lab Chip, 2012,12, 3249-3266
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    Microfluidic designs and techniques using lab-on-a-chip devices for pathogen detection for point-of-care diagnostics

    A. M. Foudeh, T. Fatanat Didar, T. Veres and M. Tabrizian, Lab Chip, 2012, 12, 3249
    DOI: 10.1039/C2LC40630F

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