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Issue 15, 2012
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A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

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We present a novel technology for the simultaneous and simple impedimetric screening of multiple microfluidic channels with only one electrode pair. We have exploited the frequency dimension to distinguish between up to three channels. Each ‘sub-sensor’ possesses its corresponding measurement frequency where the sample-specific dielectric properties can be probed. We have shown the validity of our frequency-multiplexing impedance sensor (FMIS) by comparison with conventional ‘single sensors’. Our highly sensitive FMIS was proven suitable for life science applications through usage as a cell-based toxicology platform. We are confident that our technology might find great utility in parallelized cell-based analysis systems as well as in biomedical devices where size limitations and spatially distributed probing are important parameters.

Graphical abstract: A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

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Publication details

The article was received on 07 Mar 2012, accepted on 23 Apr 2012 and first published on 24 Apr 2012

Article type: Paper
DOI: 10.1039/C2LC40236J
Citation: Lab Chip, 2012,12, 2712-2718
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    A microfluidic-based frequency-multiplexing impedance sensor (FMIS)

    R. Meissner, P. Joris, B. Eker, A. Bertsch and P. Renaud, Lab Chip, 2012, 12, 2712
    DOI: 10.1039/C2LC40236J

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