Jump to main content
Jump to site search

Issue 10, 2012
Previous Article Next Article

Microfluidic approaches for cancer cell detection, characterization, and separation

Author affiliations

Abstract

This article reviews the recent developments in microfluidic technologies for in vitro cancer diagnosis. We summarize the working principles and experimental results of key microfluidic platforms for cancer cell detection, characterization, and separation based on cell-affinity micro-chromatography, magnetic activated micro-sorting, and cellular biophysics (e.g., cell size and mechanical and electrical properties). We examine the advantages and limitations of each technique and discuss future research opportunities for improving device throughput and purity, and for enabling on-chip analysis of captured cancer cells.

Graphical abstract: Microfluidic approaches for cancer cell detection, characterization, and separation

Back to tab navigation

Publication details

The article was received on 21 Dec 2011, accepted on 10 Feb 2012 and first published on 15 Feb 2012


Article type: Critical Review
DOI: 10.1039/C2LC21273K
Citation: Lab Chip, 2012,12, 1753-1767
  •   Request permissions

    Microfluidic approaches for cancer cell detection, characterization, and separation

    J. Chen, J. Li and Y. Sun, Lab Chip, 2012, 12, 1753
    DOI: 10.1039/C2LC21273K

Search articles by author

Spotlight

Advertisements