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School of Engineering and Applied Sciences/Department of Physics, Harvard University, Cambridge, USA
E-mail: weitz@seas.harvard.edu
; Tel: +1 617-495-3275
b
UCSF School of Pharmacy, Department of Bioengineering and Therapeutic Sciences, San Francisco, USA
E-mail: adam.abate@ucsf.edu
; Tel: +1 415-476-9819
Shell Oil Company/Innovation Research and Development (IRD), Westhollow Technology Center, Houston
E-mail: rhutesh.shah@shell.com
; Tel: +1 281-544-7140
Lab Chip, 2012,12, 2135-2145
DOI:
10.1039/C2LC21164E
Received
25 Nov 2011,
Accepted
07 Mar 2012
First published online
14 Mar 2012
We describe droplet microfluidic strategies used to fabricate advanced microparticles that are useful structures for the encapsulation and release of actives; these strategies can be further developed to produce microparticles for advanced drug delivery applications. Microfluidics enables exquisite control in the fabrication of polymer vesicles and thermosensitive microgels from single and higher-order multiple emulsion templates. The strategies used to create the diversity of microparticle structures described in this review, coupled with the scalability of microfluidics, will enable fabrication of large quantities of novel microparticle structures that have potential uses in controlled drug release applications.
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