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Issue 13, 2012
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Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

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Abstract

Solid-state micropores can provide direct information of ex vivo or in vitro cell populations. Micropores are used to detect and discriminate cancer cells based on the translocation behavior through micropores. The approach provides rapid detection of cell types based on their size and mechano-physical properties like elasticity, viscosity and stiffness. Use of a single micropore device enables detection of tumor cells from whole blood efficiently, at 70% CTC detection efficiency. The CTCs show characteristic electrical signals which easily distinguish these from other cell types. The approach provides a gentle and inexpensive instrument that can be used for specific blood analysis in a lab-on-a-chip setting. The device does not require any preprocessing of the blood sample, particles/beads attachment, surface functionalization or fluorescent tags and provides quantitative and objective detection of cancer cells.

Graphical abstract: Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

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Publication details

The article was received on 20 Oct 2011, accepted on 12 Mar 2012 and first published on 01 May 2012


Article type: Paper
DOI: 10.1039/C2LC21012F
Citation: Lab Chip, 2012,12, 2345-2352
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    Electrical fingerprinting, 3D profiling and detection of tumor cells with solid-state micropores

    W. Asghar, Y. Wan, A. Ilyas, R. Bachoo, Y. Kim and S. M. Iqbal, Lab Chip, 2012, 12, 2345
    DOI: 10.1039/C2LC21012F

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