Jump to main content
Jump to site search

Issue 3, 2012
Previous Article Next Article

Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites

Author affiliations

Abstract

In medical facilities, there is strong motivation to develop detection systems that can provide continuous analysis of fluids in medical tubing used to either deliver or remove fluids from a patient's body. Possible applications include systems that increase the safety of intravenous (IV) drug injection and point-of-care health monitoring. In this work, we incorporated a surface-enhanced Raman scattering (SERS) sensor comprised of an array of closely spaced metal nanodomes into flexible tubing commonly used for IV drug delivery and urinary catheters. The nanodome sensor was fabricated by a low-cost, large-area process that enables single use disposable operation. As exemplary demonstrations, the sensor was used to kinetically detect promethazine (pain medication) and urea (urinary metabolite) within their clinically relevant concentration ranges. Distinct SERS peaks for each analyte were used to demonstrate separate detection and co-detection of the analytes.

Graphical abstract: Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 30 Jun 2011, accepted on 30 Nov 2011 and first published on 12 Dec 2011


Article type: Paper
DOI: 10.1039/C2LC20586F
Citation: Lab Chip, 2012,12, 574-581
  •   Request permissions

    Biochemical sensor tubing for point-of-care monitoring of intravenous drugs and metabolites

    C. J. Choi, H. Wu, S. George, J. Weyhenmeyer and B. T. Cunningham, Lab Chip, 2012, 12, 574
    DOI: 10.1039/C2LC20586F

Search articles by author