Jump to main content
Jump to site search

Issue 1, 2012
Previous Article Next Article

Lateral cavity acoustic transducer as an on-chip cell/particle microfluidic switch

Author affiliations

Abstract

A novel on-chip microfluidic switch is demonstrated that utilizes the acoustic microstreaming generated by an oscillating air–liquid interface to switch cells/particles into bifurcating microchannels. The air–liquid interface of the Lateral Cavity Acoustic Transducers (LCATs) can be actuated by an external acoustic energy source causing the interface to oscillate. The oscillating interface results in the generation of vortex-like microstreaming flow within a localized region of the surrounding liquid. This streaming was utilized here to deflect cells/particles into a collection outlet. It was demonstrated that the switching zone could be controlled by varying the actuation time of the LCAT. An LCAT based microfluidic switch is capable of achieving theoretical switching rates of 800 cells/particles per second. It was also demonstrated that K562 cells could be switched into a collection channel with cell viability comparable to that of controls as determined by Trypan blue exclusion assay.

Graphical abstract: Lateral cavity acoustic transducer as an on-chip cell/particle microfluidic switch

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 12 Jul 2011, accepted on 08 Sep 2011 and first published on 10 Nov 2011


Article type: Paper
DOI: 10.1039/C1LC20626E
Citation: Lab Chip, 2012,12, 139-145
  •   Request permissions

    Lateral cavity acoustic transducer as an on-chip cell/particle microfluidic switch

    M. V. Patel, A. R. Tovar and A. P. Lee, Lab Chip, 2012, 12, 139
    DOI: 10.1039/C1LC20626E

Search articles by author