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Issue 48, 2012
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Enhanced protein-mediated binding between oligonucleotidegold nanoparticle composites and cell surfaces: co-transport of proteins and composites

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Abstract

The measurement of the binding force between a cell membrane and an oligonucleotide-functionalized, gold-coated tip using atomic force microscope force spectroscopy showed enhanced binding forces due to the presence of proteins in the buffer. The cellular uptake of oligonucleotidegold nanoparticle composites was also enhanced when the composites were coated with serum proteins. Confocal microscopy image analysis of fluorescently labeled serum proteins and the oligonucleotides of the composites revealed co-transport of proteins and the composites.

Graphical abstract: Enhanced protein-mediated binding between oligonucleotide–gold nanoparticle composites and cell surfaces: co-transport of proteins and composites

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Publication details

The article was received on 22 Jun 2012, accepted on 04 Oct 2012 and first published on 17 Oct 2012


Article type: Paper
DOI: 10.1039/C2JM34047J
Citation: J. Mater. Chem., 2012,22, 25036-25041
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    Enhanced protein-mediated binding between oligonucleotidegold nanoparticle composites and cell surfaces: co-transport of proteins and composites

    Y. J. Kim, S. Ryou, S. Kim, J. Yeom, M. S. Han, K. Lee and M. Seong, J. Mater. Chem., 2012, 22, 25036
    DOI: 10.1039/C2JM34047J

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