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Issue 14, 2012
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The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA

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Abstract

Functionalized graphene oxide (GO) for the targeted intracellular delivery of hTERT siRNA was prepared by conjugating GO with polyethylene glycol (PEG) and folic acid, followed by the loading of siRNA with the aid of 1-pyrenemethylamine hydrochloride via π–π stacking. It was found that it could target the HeLa in vitro and the transfected hTERT siRNA could knockdown the protein expression level and mRNA level efficiently.

Graphical abstract: The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA

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Publication details

The article was received on 22 Sep 2011, accepted on 07 Feb 2012 and first published on 24 Feb 2012


Article type: Paper
DOI: 10.1039/C2JM14718A
Citation: J. Mater. Chem., 2012,22, 6649-6654
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    The preparation of functionalized graphene oxide for targeted intracellular delivery of siRNA

    X. Yang, G. Niu, X. Cao, Y. Wen, R. Xiang, H. Duan and Y. Chen, J. Mater. Chem., 2012, 22, 6649
    DOI: 10.1039/C2JM14718A

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