Jump to main content
Jump to site search

Issue 18, 2012
Previous Article Next Article

Tumor-binding prodrug micelles of polymerdrug conjugates for anticancer therapy in HeLa cells

Author affiliations

Abstract

An interesting phytosphingosine (PHS), a natural sphingolipid metabolite comprising ceramides, is believed to play a vital role in strong anticancer therapeutic efficacy for various types of cancer cells, which is based on a programmed cellular death mechanism, so called apoptosis. However, extremely low water-solubility has been an obstacle to its usage as an anticancer drug via the systemic administration route. To utilize the benefits of PHS, we developed tumor-targeting polymerdrug conjugates wherein hydrophobic PHS was connected to the folate-grafted hydrophilic and biocompatible polymer through pH-sensitive linkages. The polymerdrug conjugates formed nano-sized (10–20 nm) spherical micelles spontaneously in aqueous media and they were found to have high drug contents (10.3 wt%). We present a systematic study of in vitro anticancer therapy in HeLa cells treated by tumor-targeting micelles in terms of anti-proliferation. The anticancer effect was analyzed by apoptotic cell death as well as the preferential distribution of loaded drug in the cancer cells. The synergistic effect by loading the commercial drug of doxorubicin was also studied.

Graphical abstract: Tumor-binding prodrug micelles of polymer–drug conjugates for anticancer therapy in HeLa cells

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jan 2012, accepted on 12 Mar 2012 and first published on 14 Mar 2012


Article type: Paper
DOI: 10.1039/C2JM30534H
Citation: J. Mater. Chem., 2012,22, 9385-9394
  •   Request permissions

    Tumor-binding prodrug micelles of polymerdrug conjugates for anticancer therapy in HeLa cells

    B. Jung, Y. Jeong, J. Min, J. Kim, Y. Song, J. Park, J. Park and J. Kim, J. Mater. Chem., 2012, 22, 9385
    DOI: 10.1039/C2JM30534H

Search articles by author

Spotlight

Advertisements