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Issue 19, 2012
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Facile and universal immobilization of L-lysine inspired by mussels

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Abstract

A novel functional molecule lysine-dopamine (LDA) was successfully synthesized and explored as a universal modifier for different types of surfaces, inspired by mussel adhesive moiety dopamine and bio-functional moiety L-lysine. The universal, robust, and efficient surface modification based on LDA was achieved through a facile and cost-effective dip-coating process, confirmed by Fourier transform infrared spectroscopy (FTIR), contact angle, X-ray photoelectron spectroscopy (XPS) and scanning electron microscope-energy dispersive spectroscopy (SEM-EDS) measurements. Meanwhile, LDA modification improved cell adhesion, promoted cell growth, and accelerated endothelialization on the substrate surface and provided plasma clot lysis activity. The results indicated that the surface biocompatibility was obviously improved by the one-step modification method for the immobilized L-lysine.

Graphical abstract: Facile and universal immobilization of l-lysine inspired by mussels

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Publication details

The article was received on 14 Dec 2011, accepted on 23 Mar 2012 and first published on 13 Apr 2012


Article type: Paper
DOI: 10.1039/C2JM16598H
Citation: J. Mater. Chem., 2012,22, 10035-10041
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    Facile and universal immobilization of L-lysine inspired by mussels

    P. Sun, H. Lu, X. Yao, X. Tu, Z. Zheng and X. Wang, J. Mater. Chem., 2012, 22, 10035
    DOI: 10.1039/C2JM16598H

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