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Issue 16, 2012
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Biofabrication: programmable assembly of polysaccharide hydrogels in microfluidics as biocompatible scaffolds

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Abstract

Because of their stimuli-responsiveness to chemical and pH gradients, polysaccharide hydrogels such as chitosan and alginate can be assembled as scaffolds for biomolecules or cells. Using the electrical and flow control available in microfluidic networks, in situ fabrication of 3D hydrogel scaffolds can be programmed in space and time to arrange biological components as an in vitro biochemically communicating system. Flexible in situ on-demand construction of a biocompatible scaffold within microfluidics holds promise for the assembly of biological components and systems for in vitro analysis and investigation. We foresee a wide spectrum applications ranging from replication of metabolic pathways as testbeds for drug discovery to identification of cell signaling mechanisms and observation of cellular response.

Graphical abstract: Biofabrication: programmable assembly of polysaccharide hydrogels in microfluidics as biocompatible scaffolds

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Publication details

The article was received on 28 Nov 2011, accepted on 17 Feb 2012 and first published on 22 Feb 2012


Article type: Highlight
DOI: 10.1039/C2JM16215F
Citation: J. Mater. Chem., 2012,22, 7659-7666
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    Biofabrication: programmable assembly of polysaccharide hydrogels in microfluidics as biocompatible scaffolds

    Y. Cheng, X. Luo, G. F. Payne and G. W. Rubloff, J. Mater. Chem., 2012, 22, 7659
    DOI: 10.1039/C2JM16215F

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