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King's College London, BHF Centre of Research Excellence & NIHR Biomedical Research Centre at King's Health Partners, Academic Department of Surgery, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, United Kingdom
; Fax: 44 207 9288742
; Tel: 44 207 1880214
BioPhysics Group, Department of Mechanical Engineering, University College London, Torrington Place, London, WC1E 7JE
; Fax: 44 207 3880180
; Tel: 44 207 6792690
Integr. Biol., 2012,4, 628-632
20 Feb 2012,
20 Apr 2012
First published online
26 Apr 2012
Therapeutic neovascularisation using angiogenic cells has been hampered by the loss of cells from the target tissue. Encapsulation of these cells within a semi-permeable membrane could improve their retention within the ischaemic tissue without affecting the excretion of the angiogenic growth factors produced. Bio-spraying is a novel cell-handling technique that does not adversely affect cell viability. We used this technique to encapsulate human peripheral blood monocytes and found that cell viability, cell phenotype and functional downstream angiogenic signalling were preserved. Encapsulation of monocytes with macrophage-colony stimulating factor resulted in increased vascular-endothelial growth factor production and enhanced angiogenic function. Bio-spraying/encapsulation has the potential to enhance the efficacy of current angiogenic cell therapy strategies and merits further investigation.
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