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Issue 5, 2012
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Investigation of in vivo microtubule and stress fiber mechanics with laser ablation

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Abstract

Laser ablation has emerged as a useful technique to study the mechanical properties of the cytoskeleton in living cells. Laser ablation perturbs the force balance in the cytoskeleton, resulting in a dynamic response which can be imaged. Quantitative measurement of the dynamic response allows the testing of mechanical theories of the cytoskeleton in living cells. This review discusses recent work in applying laser ablation to study stress fiber and microtubule mechanics in living endothelial cells. These studies reveal that molecular motors are major determinants of the mechanical properties of the cytoskeleton in cells.

Graphical abstract: Investigation of in vivo microtubule and stress fiber mechanics with laser ablation

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Publication details

The article was received on 27 Jan 2012, accepted on 18 Mar 2012 and first published on 21 Mar 2012


Article type: Review Article
DOI: 10.1039/C2IB20015E
Citation: Integr. Biol., 2012,4, 471-479
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    Investigation of in vivo microtubule and stress fiber mechanics with laser ablation

    J. Wu, R. B. Dickinson and T. P. Lele, Integr. Biol., 2012, 4, 471
    DOI: 10.1039/C2IB20015E

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