Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 5, 2012
Previous Article Next Article

Investigation of in vivo microtubule and stress fiber mechanics with laser ablation

Author affiliations

Abstract

Laser ablation has emerged as a useful technique to study the mechanical properties of the cytoskeleton in living cells. Laser ablation perturbs the force balance in the cytoskeleton, resulting in a dynamic response which can be imaged. Quantitative measurement of the dynamic response allows the testing of mechanical theories of the cytoskeleton in living cells. This review discusses recent work in applying laser ablation to study stress fiber and microtubule mechanics in living endothelial cells. These studies reveal that molecular motors are major determinants of the mechanical properties of the cytoskeleton in cells.

Graphical abstract: Investigation of in vivo microtubule and stress fiber mechanics with laser ablation

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 27 Jan 2012, accepted on 18 Mar 2012 and first published on 21 Mar 2012


Article type: Review Article
DOI: 10.1039/C2IB20015E
Citation: Integr. Biol., 2012,4, 471-479
  •   Request permissions

    Investigation of in vivo microtubule and stress fiber mechanics with laser ablation

    J. Wu, R. B. Dickinson and T. P. Lele, Integr. Biol., 2012, 4, 471
    DOI: 10.1039/C2IB20015E

Search articles by author