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Issue 11, 2012
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Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

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Abstract

Replacement of dichloromethane as the bulk medium within chromatographic purification has been evaluated with a broad range of molecules containing functionality common within Medicinal Chemistry programmes. Analysis of the data set has generated a set of general guidelines to assist in the selection of alternative solvents for CH2Cl2 as the bulk media in these ubiquitously employed processes.

Graphical abstract: Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

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Publication details

The article was received on 30 Aug 2012, accepted on 28 Sep 2012 and first published on 02 Oct 2012


Article type: Communication
DOI: 10.1039/C2GC36378J
Citation: Green Chem., 2012,14, 3016-3019
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    Replacement of dichloromethane within chromatographic purification: a guide to alternative solvents

    D. S. MacMillan, J. Murray, H. F. Sneddon, C. Jamieson and A. J. B. Watson, Green Chem., 2012, 14, 3016
    DOI: 10.1039/C2GC36378J

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