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Issue 7, 2012
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Robust eco-friendly protocol for the preparation of γ-hydroxy-α,β-acetylenic esters by sequential one-pot elimination–addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF

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Abstract

An efficient and widely applicable preparation of γ-hydroxy-α,β-acetylenic esters is described by means of a one-pot dehydrobromination of a 2-bromoacrylate ester with LTMP followed by the electrophilic addition of the transient propiolate to different aldehydes in the eco-friendly solvent 2-MeTHF.

Graphical abstract: Robust eco-friendly protocol for the preparation of γ-hydroxy-α,β-acetylenic esters by sequential one-pot elimination–addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF

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Publication details

The article was received on 29 Feb 2012, accepted on 24 Apr 2012 and first published on 25 Apr 2012


Article type: Communication
DOI: 10.1039/C2GC35305A
Citation: Green Chem., 2012,14, 1859-1863
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    Robust eco-friendly protocol for the preparation of γ-hydroxy-α,β-acetylenic esters by sequential one-pot elimination–addition of 2-bromoacrylates to aldehydes promoted by LTMP in 2-MeTHF

    V. Pace, L. Castoldi, A. R. Alcántara and W. Holzer, Green Chem., 2012, 14, 1859
    DOI: 10.1039/C2GC35305A

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