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Issue 7, 2012
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“On water” direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives

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Abstract

A novel protocol for the direct arylation of thiazolo[5,4-d]pyrimidine derivatives with aryl iodides is reported. The reactions were catalysed by a combination of Pd(PPh3)4 and Ag2CO3 (acting as the oxidant and the base as well), using exclusively water as the solvent and furnishing the desired products in good to excellent yields at only 60 °C.

Graphical abstract: “On water” direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives

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Publication details

The article was received on 19 Mar 2012, accepted on 26 Apr 2012 and first published on 26 Apr 2012


Article type: Paper
DOI: 10.1039/C2GC35399G
Citation: Green Chem., 2012,14, 1979-1981
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    “On water” direct Pd-catalysed C–H arylation of thiazolo[5,4-d]pyrimidine derivatives

    Y. Su, Y. Deng, T. Ma, Y. Li and L. Sun, Green Chem., 2012, 14, 1979
    DOI: 10.1039/C2GC35399G

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