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Issue 7, 2012
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The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel

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Abstract

The mucus layer covering the epithelial surface of the gastrointestinal tract serves as the front line of protection against the luminal contents and plays a key role in the establishment and activity of the commensal microbiota. The composition and complexity of the bacterial community within this environment is altered by the introduction of fermentable dietary components. These dietary components can change the metabolic end products of bacterial fermentation, which in turn are able to modify the expression of mucin genes and proteins leading to an increase in the mucus layer thickness. This review introduces some of the key interactions between fermentable carbohydrates, commensal bacteria, and intestinal cells which influence mucin production.

Graphical abstract: The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel

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Publication details

The article was received on 29 Jan 2012, accepted on 09 Apr 2012 and first published on 13 Apr 2012


Article type: Review Article
DOI: 10.1039/C2FO30017F
Citation: Food Funct., 2012,3, 690-699
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    The interactions between endogenous bacteria, dietary components and the mucus layer of the large bowel

    A. M. Barnett, N. C. Roy, W. C. McNabb and A. L. Cookson, Food Funct., 2012, 3, 690
    DOI: 10.1039/C2FO30017F

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