Amino acids form prenucleation clusters: ESI-MS as a fast detection method in comparison to analytical ultracentrifugation

Matthias Kellermeier; Rose Rosenberg; Adrian Moise; Ulrike Anders; Michael Przybylski; Helmut Cölfen

doi:10.1039/C2FD20060K

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Faraday Discussions

Issue 1, 2012

Discussion summary and research papers, in physical chemistry, chemical physics and biophysical chemistry.

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Amino acids form prenucleation clusters: ESI-MS as a fast detection method in comparison to analytical ultracentrifugation

Matthias Kellermeier,^a Rose Rosenberg,^a Adrian Moise,^b Ulrike Anders,^a^b Michael Przybylski^b and Helmut Cölfen*^a

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University of Konstanz, Physical Chemistry, Universitätsstr. 10, D-78457 Konstanz
E-mail: helmut.coelfen@uni-konstanz.de ;
Fax: +49-7531-883091 ;
Tel: +49-7531-884063

University of Konstanz, Analytical Chemistry, Universitätsstr. 10, D-78457 Konstanz
E-mail: michael.przybylski@uni-konstanz.de ;
Fax: +49-7531-883097 ;
Tel: +49-7531-882249

Faraday Discuss., 2012,159, 23-45

DOI: 10.1039/C2FD20060K
Received 30 Mar 2012, Accepted 11 May 2012
First published online 14 May 2012

This article is part of themed collection: Crystallisation – A Biological Perspective

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Electrospray ionisation mass spectrometry (ESI-MS) is a fast method which is able to provide molecular mass information with high precision. In this contribution, we show that prenucleation clusters—species recently found to play a pivotal role in crystallisation processes—are detected in addition to monomers by analytical ultracentrifugation (AUC) for the whole range of DL-amino acids, while higher oligomers are simultaneously observed in ESI-MS spectra. This suggests ESI-MS is a fast method to identify systems, which form prenucleation clusters. The occurrence of these clusters as relevant precursors in non-classical nucleation scenarios thus appears to be a more common phenomenon than so far assumed.

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Matthias Kellermeier
Rose Rosenberg
Adrian Moise
Ulrike Anders
Michael Przybylski
Helmut Cölfen

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