CaCO3/Chitin hybrids: recombinant acidic peptides based on a peptide extracted from the exoskeleton of a crayfish controls the structures of the hybrids

Hiromu Kumagai; Ryou Matsunaga; Tatsuya Nishimura; Yuya Yamamoto; Satoshi Kajiyama; Yuya Oaki; Kei Akaiwa; Hirotaka Inoue; Hiromichi Nagasawa; Kohei Tsumoto; Takashi Kato

doi:10.1039/C2FD20057K

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Faraday Discussions

Issue 1, 2012

Discussion summary and research papers, in physical chemistry, chemical physics and biophysical chemistry.

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CaCO₃/Chitin hybrids: recombinant acidic peptides based on a peptide extracted from the exoskeleton of a crayfish controls the structures of the hybrids

Hiromu Kumagai,^a Ryou Matsunaga,^b Tatsuya Nishimura,*^a Yuya Yamamoto,^a Satoshi Kajiyama,^a Yuya Oaki,^a Kei Akaiwa,^a Hirotaka Inoue,^c Hiromichi Nagasawa,^c Kohei Tsumoto^b^d and Takashi Kato*^a

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Department of Chemistry and Biotechnology, School of Engineering, University of Tokyo, Bunkyo-ku, Japan
E-mail: kato@chiral.t.u-tokyo.ac.jp

Department of Medical Genome Science, School of Frontier Sciences, University of Tokyo, Kashiwa, Japan

Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, University of Tokyo, Bunkyo-ku, Japan

Medical Proteomics Laboratory, Institute of Medical Science, University of Tokyo, Minato-ku, Japan

Faraday Discuss., 2012,159, 483-494

DOI: 10.1039/C2FD20057K
Received 27 Mar 2012, Accepted 06 Jun 2012
First published online 13 Aug 2012

This article is part of themed collection: Crystallisation – A Biological Perspective

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Functional peptides play an important role in the formation of biominerals. Here we focus on peptides involved in mineralization of the exoskeleton of a crayfish. New recombinant peptides are designed and synthesized on the basis of an acidic functional peptide, CAP-1, derived from the exoskeleton of a crayfish. We have examined the effect of these peptides on the hybrid formation of calcium carbonate and organic molecules in aqueous solution. In the presence of these recombinant peptides having chitin binding moieties, platelike tripodal calcite crystals are formed on the chitin matrix with unidirectional crystallographic orientation. Two kinds of interactions, (1) interactions between an acidic part of the peptides and calcium ions and (2) specific binding interactions of the peptides to chitin, are essential for the formation of the oriented crystals and the induction of specific morphologies. Moreover, the sizes of crystallites decrease with increasing the number of acidic parts of mutational peptides. The bioinspired design of peptides that control the interface of inorganic and organic domains may pave the way for an opportunity to build new hybrid structures.

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CaCO₃/Chitin hybrids: recombinant acidic peptides based on a peptide extracted from the exoskeleton of a crayfish controls the structures of the hybrids

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CaCO3/Chitin hybrids: recombinant acidic peptides based on a peptide extracted from the exoskeleton of a crayfish controls the structures of the hybrids

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CaCO₃/Chitin hybrids: recombinant acidic peptides based on a peptide extracted from the exoskeleton of a crayfish controls the structures of the hybrids