Centro de Química, Campus de Gualtar, Universidade do Minho, 4710-057 Braga, Portugal
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Laboratoire de Chimie Inorganique et Bioinorganique, Ecole Polytechnique Féderale de Lausanne, EPFL-BCH CH-1015 Lausanne, Switzerland
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Department of Life Sciences, Faculty of Science and Technology, and Center of Neurosciences and Cell Biology, University of Coimbra, P.O. Box 3046, 3001-401 Coimbra, Portugal
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Dalton Trans., 2012,41, 5472-5475
18 Feb 2012,
13 Mar 2012
First published online
13 Mar 2012
Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM−1 s−1, 30 MHz, 25 °C) contrast agent potentially safe for in vivo MRI applications. The Lipari–Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.
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