Jump to main content
Jump to site search

Issue 18, 2012
Previous Article Next Article

Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

Author affiliations

Abstract

Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM−1 s−1, 30 MHz, 25 °C) contrast agent potentially safe for in vivo MRI applications. The Lipari–Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the relaxivity of the gold nanoparticles. The effect of fast water exchange on the relaxivity of gold nanoparticles functionalized with Gd3+ chelates is also addressed in this communication.

Graphical abstract: Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

Back to tab navigation

Supplementary files

Publication details

The article was received on 18 Feb 2012, accepted on 13 Mar 2012 and first published on 13 Mar 2012


Article type: Communication
DOI: 10.1039/C2DT30388D
Citation: Dalton Trans., 2012,41, 5472-5475
  •   Request permissions

    Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chelates as high relaxivity contrast agents for MRI

    M. F. Ferreira, B. Mousavi, P. M. Ferreira, C. I. O. Martins, L. Helm, J. A. Martins and C. F. G. C. Geraldes, Dalton Trans., 2012, 41, 5472
    DOI: 10.1039/C2DT30388D

Search articles by author

Spotlight

Advertisements