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Issue 13, 2012
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Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

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Abstract

A diverse library of cationic silver complexes bearing bis(N-heterocyclic carbene) ligands have been prepared which exhibit cytotoxicity comparable to cisplatin against the adenocarcinomas MCF7 and DLD1. Bidentate ligands show enhanced cytotoxicity over monodentate and macrocyclic ligands.

Graphical abstract: Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

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Publication details

The article was received on 12 Dec 2011, accepted on 05 Jan 2012 and first published on 06 Jan 2012


Article type: Paper
DOI: 10.1039/C2DT12399A
Citation: Dalton Trans., 2012,41, 3720-3725
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    Enhanced cytotoxicity of silver complexes bearing bidentate N-heterocyclic carbene ligands

    D. C. F. Monteiro, R. M. Phillips, B. D. Crossley, J. Fielden and C. E. Willans, Dalton Trans., 2012, 41, 3720
    DOI: 10.1039/C2DT12399A

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