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Issue 20, 2012
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Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

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Abstract

The rich photophysical properties of luminescent inorganic and organometallic transition metal complexes, such as their intense, long-lived, and environment-sensitive emission, render them excellent candidates for biological and cellular studies. In this Perspective, we review examples of biological probes derived from luminescent transition metal complexes with a d6, d8, or d10 metal center. The design of luminescent covalent labels and noncovalent probes for protein molecules is discussed. Additionally, the recent applications of these complexes as cellular probes and bioimaging reagents are described. Emphasis is put on the structural features, photophysical behavior, biomolecular interactions, cellular uptake, and intracellular localization properties of luminescent transition metal complexes.

Graphical abstract: Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

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Publication details

The article was received on 07 Oct 2011, accepted on 29 Nov 2011 and first published on 13 Jan 2012


Article type: Perspective
DOI: 10.1039/C2DT11892K
Citation: Dalton Trans., 2012,41, 6021-6047
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    Applications of luminescent inorganic and organometallic transition metal complexes as biomolecular and cellular probes

    K. K. Lo, A. W. Choi and W. H. Law, Dalton Trans., 2012, 41, 6021
    DOI: 10.1039/C2DT11892K

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