Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 8, 2013
Previous Article Next Article

BODIPY-modified Ru(II) arene complex—a new ligand dissociation mechanism and a novel strategy to red shift the photoactivation wavelength of anticancer metallodrugs

Author affiliations

Abstract

A Ru(II) arene complex [(η6-p-cymene)Ru(bpy)(py-BODIPY)](PF6)2, where bpy is 2,2′-bipyridine and py-BODIPY is a 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene dye containing a pyridine group at the 8-position, was designed and synthesized. BODIPY modification renders the monodentate pyridine ligand with long wavelength absorbing capability, and an absorption maximum at 504 nm. Upon selective irradiation of the absorption band of the py-BODIPY ligand, the dissociation of the monodentate ligand occurs efficiently, followed by substitution by 9-ethylguanine if it is present in the solution. The photoinduced ligand dissociation quantum yield was measured to be 4.1% at 480 nm. The photoinduced electron transfer from the BODIPY chromophore to the Ru(II) arene moiety plays an important role in the ligand dissociation. Such a photosensitization strategy can be utilized to develop novel anticancer metallodrugs that may respond to light in the phototherapeutic window (650–900 nm).

Graphical abstract: BODIPY-modified Ru(ii) arene complex—a new ligand dissociation mechanism and a novel strategy to red shift the photoactivation wavelength of anticancer metallodrugs

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 23 Oct 2012, accepted on 29 Nov 2012 and first published on 30 Nov 2012


Article type: Paper
DOI: 10.1039/C2DT32527F
Citation: Dalton Trans., 2013,42, 2786-2791
  •   Request permissions

    BODIPY-modified Ru(II) arene complex—a new ligand dissociation mechanism and a novel strategy to red shift the photoactivation wavelength of anticancer metallodrugs

    Q. Zhou, W. Lei, Y. Hou, Y. Chen, C. Li, B. Zhang and X. Wang, Dalton Trans., 2013, 42, 2786
    DOI: 10.1039/C2DT32527F

Search articles by author