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Issue 9, 2013
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Bacterial sensor kinases using Fe–S cluster binding PAS or GAF domains for O2 sensing

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Abstract

[4Fe–4S]2+ clusters are used by very diverse types of bacterial sensors for response to oxygen, including DNA-binding proteins of the CRP/FNR family and sensor kinases like NreB. In NreB the cluster is bound by an input domain of the PAS type. The [4Fe–4S]2+ cluster of NreB responds to O2 by degradation to a [2Fe–2S]2+ cluster which is labile and decomposes. NreB constitutes together with AirS the NreB/AirS family of bacterial sensor kinases that contain PAS or GAF domains for binding of [4Fe–4S]2+ or [2Fe–2S]2+ clusters and oxygen sensing. The NreB/AirS family is related to the FixL sensor kinases that use hemeB binding PAS domains for oxygen sensing.

Graphical abstract: Bacterial sensor kinases using Fe–S cluster binding PAS or GAF domains for O2 sensing

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Publication details

The article was received on 10 Sep 2012, accepted on 18 Oct 2012 and first published on 23 Oct 2012


Article type: Perspective
DOI: 10.1039/C2DT32089D
Citation: Dalton Trans., 2013,42, 3082-3087
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    Bacterial sensor kinases using Fe–S cluster binding PAS or GAF domains for O2 sensing

    G. Unden, S. Nilkens and M. Singenstreu, Dalton Trans., 2013, 42, 3082
    DOI: 10.1039/C2DT32089D

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