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Issue 9, 2013
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Human ferredoxin-2 displays a unique conformational change

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Abstract

Human ferredoxin-1 (hFd1) and human ferredoxin-2 (hFd2) share high sequence similarity but serve on distinct cellular pathways. A unique conformational change is observed when holo hFd2 is warmed to physiological temperatures, or higher. Enzymatic studies show that this conformational change causes the increase of affinity between hFd2 and adrenodoxin reductase. No such change was observed for hFd1, which may contribute to the distinct cellular functions of hFd1 and hFd2 under physiological conditions.

Graphical abstract: Human ferredoxin-2 displays a unique conformational change

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Publication details

The article was received on 01 Sep 2012, accepted on 22 Nov 2012 and first published on 22 Nov 2012


Article type: Communication
DOI: 10.1039/C2DT32018E
Citation: Dalton Trans., 2013,42, 3088-3091
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    Human ferredoxin-2 displays a unique conformational change

    W. Qi, J. Li and J. A. Cowan, Dalton Trans., 2013, 42, 3088
    DOI: 10.1039/C2DT32018E

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