Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 5, 2013
Previous Article Next Article

Preparation and characterization of ZnS:Tb,Gd and ZnS:Er,Yb,Gd nanoparticles for bimodal magnetic-fluorescent imaging

Author affiliations

Abstract

As bimodal magnetic-fluorescent imaging agents, the preparation of ZnS:Tb,Gd and ZnS:Er,Yb,Gd nanoparticles via a facile homogeneous precipitation method is reported. The results show that these nanoparticles are almost spherical in shape with a diameter of 100–200 nm approximately and a major phase of wurtzite-structured ZnS. The products can successfully label the human hepatocellular carcinoma (HepG2) cells and present low toxicity even at concentrations up to 5 mg mL−1. Additionally, for the ZnS:Er,Yb,Gd nanoparticles calcinated above 950 °C, NIR-to-visible up-conversion fluorescence were obtained, which is believed to be superior to traditional ZnS-based bioimaging agents with down conversion. In MRI studies, they reveal a longitudinal relaxivity rate (r1) of 39.46 mM−1 s−1 and 57.8 mM−1 s−1, respectively, which are much larger than the conventional Gd-DTPA and currently reported Gd-base nanoparticles, suggesting great potential as MRI agents.

Graphical abstract: Preparation and characterization of ZnS:Tb,Gd and ZnS:Er,Yb,Gd nanoparticles for bimodal magnetic-fluorescent imaging

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 04 Aug 2012, accepted on 29 Oct 2012 and first published on 29 Oct 2012


Article type: Paper
DOI: 10.1039/C2DT31783D
Citation: Dalton Trans., 2013,42, 1752-1759
  •   Request permissions

    Preparation and characterization of ZnS:Tb,Gd and ZnS:Er,Yb,Gd nanoparticles for bimodal magnetic-fluorescent imaging

    X. Wei, W. Wang and K. Chen, Dalton Trans., 2013, 42, 1752
    DOI: 10.1039/C2DT31783D

Search articles by author