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Department of Coordination Chemistry, International Key Laboratory of Shenyang Inorganic Molecule-Based Chemistry, Shenyang University of Chemical Technology, Shenyang 110142, China
; Fax: +86 24 89388211
; Tel: +86 24 89385016
Dalton Trans., 2012,41, 13352-13358
22 Jul 2012,
29 Aug 2012
First published online
31 Aug 2012
The organic ligand Hbpmc and the polymeric complex [Mn(bpmc)2(4,4′-bipy)(H2O)2]n·3H2O (4,4′-bipy = 4,4′-bipyridine, Hbpmc = 2,2-bis(3-phenylpropyl) malonic acid), which have both a lipophilic group (aromatic ring) and a hydrophilic group (non-coordination carboxyl), were synthesized and characterized by IR spectra, elemental analysis and X-ray single-crystal diffraction. The interaction of the complexes with HC-DNA was investigated by fluorescence spectroscopy. Gel electrophoresis assay demonstrates the ability to cleave the extracted HC-DNA. The value of IC50 is to understand the effect of cytotoxic activity which is lower than cisplatin and higher than the ligand Hbpmc. The apoptotic tests show that the complexes apparently have an apoptotic effect on Hela cells.
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