without changing your settings we'll assume you are happy to receive all RSC cookies.
You can change your cookie settings by navigating to our Privacy and Cookies page and following the instructions. These instructions
are also obtainable from the privacy link at the bottom of any RSC page.
The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, USA
; Fax: +1 214-645-2885
; Tel: +1 214-645-5978
Instituto Nacional de Investigaciones Nucleares, Carretera México-Toluca S/N, La Marquesa, Ocoyoacac, Estado de México, México
; Fax: +52 555-329-7306
; Tel: +52 555-329-7200
Universidad de Guanajuato, Cerro de la Venada S/N, Guanajuato, México
; Fax: +52 473-732-6252
Dalton Trans., 2012,41, 14051-14054
08 Jul 2012,
01 Oct 2012
First published online
22 Oct 2012
Two bicyclic compounds containing Arg-Gly-Asp (RGD) motifs (RGDf and RGD) were synthesized by cyclizing the peptide sequence across the macrocyclic ring of DOTA via two non-adjacent carboxylate pendent arms. The Lu3+ or Cu2+ complexes of these compounds, c(DOTA-RGDf) and c(DOTA-RGD), showed a metal dependent affinity towards integrin αvβ3in vitro and the 177Lu3+ or 64Cu2+ labelled derivatives showed specific tumour uptake in MCF7 and U87MG tumour bearing mice.
Fetching data from CrossRef. This may take some time to load.