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Issue 38, 2012
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Remarkable in vitro bactericidal activity of bismuth(III) sulfonates against Helicobacter pylori

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Abstract

Four new tris-substituted bismuth(III) sulfonates of general formula [Bi(O3SR)3] (R = phenyl 1, p-tolyl 2, 2,4,6-mesityl 3 and S-(+)-10-camphoryl 4) have been synthesised and characterised. Their synthesis by solvent-free (SF) and solvent-mediated (SM) methods has been explored and their activity against Helicobacter pylori has been investigated. The compounds 1–4 display a remarkable in vitro activity against three laboratory strains of H. pylori (B128, 26 695 and 251) with minimum inhibitory concentration (MIC) values as low as 0.049 μg mL−1 for the strains B128 and 26 695, and 0.781 μg mL−1 for the clinical isolate 251. This places most MIC values in the nano-molar region and demonstrates the strong influence of the sulfonate group on the bactericidal properties. The novel solid state structure [Bi8(O3SMes)20(SO4)2(H2O)6]·(C7H8)75·(C777H888)777, derived from the SM reaction under reflux conditions, is presented and the incorporation of the two inorganic sulfate anions in the centre of the wheel-like bismuth sulfonate cluster explained.

Graphical abstract: Remarkable in vitro bactericidal activity of bismuth(iii) sulfonates against Helicobacter pylori

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Publication details

The article was received on 26 Jun 2012, accepted on 25 Jul 2012 and first published on 25 Jul 2012


Article type: Paper
DOI: 10.1039/C2DT31360J
Citation: Dalton Trans., 2012,41, 11798-11806
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    Remarkable in vitro bactericidal activity of bismuth(III) sulfonates against Helicobacter pylori

    P. C. Andrews, M. Busse, G. B. Deacon, R. L. Ferrero, P. C. Junk, J. G. MacLellan and A. Vom, Dalton Trans., 2012, 41, 11798
    DOI: 10.1039/C2DT31360J

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