One dodecahedral bismuth(III) complex derived from 2-acetylpyridine N(4)-pyridylthiosemicarbazone: synthesis, crystal structure and biological evaluation

Mingxue Li; Yanli Lu; Min Yang; Yanke Li; Lizhi Zhang; Songqiang Xie

doi:10.1039/C2DT31256E

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Dalton Transactions

Issue 41, 2012

The international journal for inorganic, organometallic and bioinorganic chemistry

Impact Factor 3.838 48 Issues per Year Indexed in MEDLINE

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Paper

One dodecahedral bismuth(III) complex derived from 2-acetylpyridine N(4)-pyridylthiosemicarbazone: synthesis, crystal structure and biological evaluation

Mingxue Li,*^a Yanli Lu,^a Min Yang,^a Yanke Li,^a Lizhi Zhang^a and Songqiang Xie*^b

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Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China
E-mail: limingxue@henu.edu.cn ;
Fax: (+86) 3783886876

Institute of Chemical biology, Henan University, Kaifeng 475004, PR China
E-mail: kfxsq@yahoo.com.cn

Dalton Trans., 2012,41, 12882-12887

DOI: 10.1039/C2DT31256E
Received 12 Jun 2012, Accepted 27 Aug 2012
First published online 29 Aug 2012

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One dodecahedral bismuth(III) complex [Bi(HL)(NO₃)₃] (1) (HL = 2-acetylpyridine N(4)-pyridylthiosemicarbazone) has been synthesized and structurally characterized. The analytical data reveals the formation of 1:1 (metal:ligand) stoichiometry. The bismuth(III) ion is nine-coordinated by one electron pair (6s²) of the bismuth(III) atom, two nitrogen and one sulfur atoms from the N₂S tridentate ligand and five oxygen atoms from three nitrate ions. Biological studies, carried out in vitro against eight selected bacteria, and four human cancer cells, respectively, have indicated that 1 shows better growth-inhibiting properties. Upon further investigation, 1 might produce cytotoxicity through apoptosis.