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Issue 41, 2012
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One dodecahedral bismuth(III) complex derived from 2-acetylpyridine N(4)-pyridylthiosemicarbazone: synthesis, crystal structure and biological evaluation

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Abstract

One dodecahedral bismuth(III) complex [Bi(HL)(NO3)3] (1) (HL = 2-acetylpyridine N(4)-pyridylthiosemicarbazone) has been synthesized and structurally characterized. The analytical data reveals the formation of 1 : 1 (metal : ligand) stoichiometry. The bismuth(III) ion is nine-coordinated by one electron pair (6s2) of the bismuth(III) atom, two nitrogen and one sulfur atoms from the N2S tridentate ligand and five oxygen atoms from three nitrate ions. Biological studies, carried out in vitro against eight selected bacteria, and four human cancer cells, respectively, have indicated that 1 shows better growth-inhibiting properties. Upon further investigation, 1 might produce cytotoxicity through apoptosis.

Graphical abstract: One dodecahedral bismuth(iii) complex derived from 2-acetylpyridine N(4)-pyridylthiosemicarbazone: synthesis, crystal structure and biological evaluation

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Publication details

The article was received on 12 Jun 2012, accepted on 27 Aug 2012 and first published on 29 Aug 2012


Article type: Paper
DOI: 10.1039/C2DT31256E
Citation: Dalton Trans., 2012,41, 12882-12887
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    One dodecahedral bismuth(III) complex derived from 2-acetylpyridine N(4)-pyridylthiosemicarbazone: synthesis, crystal structure and biological evaluation

    M. Li, Y. Lu, M. Yang, Y. Li, L. Zhang and S. Xie, Dalton Trans., 2012, 41, 12882
    DOI: 10.1039/C2DT31256E

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