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Issue 36, 2012
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Two new palladium(II) complexes: synthesis, characterization and their interaction with HeLa cells

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Abstract

Two complexes [Pd(L1)(en)]2·4H2O (1), [Pd(L2)(en)]·2H2O (2), (L1 = pyridine-2,3-dicarboxylic acid, L2 = pyrazine-2,3-dicarboxylic acid, and en = ethylenediamine) have been synthesized and characterized using IR, 1H NMR and element analysis. X-ray analyses of complexes 1 and 2 revealed that 1 belongs to the triclinic system with space group P[1 with combining macron](2), and 2 belongs to the monoclinic system with space group P2(1)/n. The binding of the complexes with HC-DNA (HeLa cells DNA, which was extracted by ourselves) were measured by fluorescence spectrum and viscometry. Gel electrophoresis assay demonstrates the ability of the complexes to cleave the extracted HC-DNA. The complexes exhibit a higher cytotoxicity against tumor cells as against normal cells in vitro. Further more, apoptotic tests indicate that the complexes have an apoptotic effect on HeLa cells.

Graphical abstract: Two new palladium(ii) complexes: synthesis, characterization and their interaction with HeLa cells

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Publication details

The article was received on 07 May 2012, accepted on 15 Jun 2012 and first published on 18 Jun 2012


Article type: Paper
DOI: 10.1039/C2DT30990D
Citation: Dalton Trans., 2012,41, 11187-11194
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    Two new palladium(II) complexes: synthesis, characterization and their interaction with HeLa cells

    E. Gao, L. Lin, L. Liu, M. Zhu, B. Wang and X. Gao, Dalton Trans., 2012, 41, 11187
    DOI: 10.1039/C2DT30990D

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